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In 2011, ҹɫ���� opened a second campus in collaboration with  to address healthcare shortages in upstate South Carolina. The Carolinas Campus is part of Spartanburg's  of seven colleges and universities, which offers a variety of social opportunities and benefits for students. 

The main campus building is over 70,000 square feet and is situated on a 20-acre campus.  In addition to two large theatre classrooms, 20 moderately sized rooms are available for small-group learning.  The main campus building features a state-of-the-art anatomy lab, a physical exam and osteopathic manipulative medicine training lab, a library, and student study and lounge spaces.  The Simulation and Technology Center houses cutting-edge high-fidelity human medical simulators, standardized patient examination rooms, simulated surgical and intensive care unit suites, physical diagnosis and osteopathic manual therapy training labs, simulated radiology experiences, and room for additional medical education programs.